Antibody researchers in every laboratory worldwide are trying to translate potent in vitro candidates to the clinic, one at a time. This often fails because molecules are engineered in vitro and are only much later tested in vivo. As a result, a massive number of candidates is generated that accumulate poorly in target organs and enrich in off-target organs unexpectedly high.
Linkster Therapeutics removes this translational bottleneck with superior in vivo platform technology. Important for this transformation are our advanced targeting strategies for tissue-specific delivery. Also, we excel to create conformation-specific antibody candidates against cell surface targets such as GPCRs and SLC transporters. Key remains our translational antibody engineering technology based on Flycode®
peptide barcodes. It allows us to remove unwanted events of drug penetration into unwanted tissues. And it translates antibody design into candidates with higher efficacy, better dosing windows and toxicity.