LinksterTX

Publications

Linkster Therapeutics technology is peer-reviewed and published in leading international scientific journals including Nature, Cell and Science

technology.

2022  Science Advances

The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells

Authors: L. Galazzo, G. Meier, D. Januliene, K. Parey, D. D. Vecchis, B. Striednig, H. Hilbi, L. V. Schäfer, I. Kuprov, A. Moeller, E. Bordignon, M. A. Seeger

2020  Nature protocols

Generation of synthetic nanobodies against delicate proteins

Authors: I. Zimmermann, P. Egloff, C. A. J. Hutter, B. T. Kuhn, P. Bräuer, S. Newstead, R. J. P. Dawson, E. R. Geertsma, M. A. Seeger

2019  Nature methods

Engineered peptide barcodes for in-depth analyses of binding protein libraries

Authors: P. Egloff, I. Zimmermann, F. M. Arnold, C. A. J. Hutter, D. Morger, L. Opitz, L. Poveda, H. A. Keserue, C. Panse, B. Roschitzki & M. A. Seeger

2018  Nature Communications

Development of an antibody fragment that stabilizes GPCR/G-protein complexes

Authors: S. Maeda, A. Koehl, H. Matile, H. Hu, D. Hilger, G. F. X. Schertler, A. Manglik, G. Skiniotis, R. J. P. Dawson, B. K. Kobilka

2018  eLife

Synthetic single domain antibodies for the conformational trapping of membrane proteins

Authors: I. Zimmermann, P. Egloff, C. A. J. Hutter, F. M. Arnold, P. Stohler, N. Bocquet, M. N. Hug, S. Huber, M. Siegrist, L. Hetemann, J. Gera, S. Gmür, P. Spies, D. Gygax, E. R. Geertsma, R. J. P. Dawson, M. A. Seeger

Transporter.

2022 Nature Communications

Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation

Authors: M. Botte, D. Ni, S. Schenck, I. Zimmermann, M. Chami, N. Bocquet, P. Egloff, D. Bucher, M. Trabuco, R. K. Y. Cheng, J. D. Brunner, M. A. Seeger, H. Stahlberg & M. Hennig

2022 Science Advances

Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification

Authors: N. Bärland, A. Rueff, G. Cebrero, C. A. J. Hutter, M. A. Seeger, J. Veening, C. Perez

2021  Nature

Kinetic mechanism of Na+-coupled aspartate transport catalyzed by GltTk

Authors: G. Trinco, V. Arkhipova, A. A. Garaeva, C. A. J. Hutter, M. A. Seeger, A. Guskov, D. J. Slotboom

2021  Nature

Structural insights into the inhibition of glycine reuptake

Authors: A. Shahsavar, P. Stohler, G. Bourenkov, I. Zimmermann, M. Siegrist, W. Guba, E. Pinard, S. Sinning, M. A. Seeger, T. R. Schneider, R. J. P. Dawson, P. Nissen

2020  Proc Natl Acad Sci U S A, 117(5): p. 2441-2448.

Spin-labeled nanobodies as protein conformational reporters for electron paramagnetic resonance in cellular membranes

Authors: L. Galazzo, G. Meier, M.H. Timachi, C.A.J. Hutter, M.A. Seeger*, and E. Bordignon*

2020  Nature

The ABC exporter IrtAB imports and reduces mycobacterial siderophores

Authors: F. M. Arnold, M. S. Weber, I. Gonda, M. J Gallenito, S. Adenau, P. Egloff, I. Zimmermann, C. A. J. Hutter, L. M. Hürlimann, E. E. Peters, J. Piel, G. Meloni, O. Medalia, M. A. Seeger

2019  Nature Communications

The extracellular gate shapes the energy profile of an ABC exporter

Authors: C. A. J. Hutter, M. H. Timachi, L. M. Hürlimann, I. Zimmermann, P. Egloff, H. Göddeke, S. Kucher, S. Štefanić, M. Karttunen, L. V. Schäfer, E. Bordignon & M. A. Seeger

2019  Nature methods

Engineered peptide barcodes for in-depth analyses of binding protein libraries

Authors: P. Egloff, I. Zimmermann, F. M. Arnold, C. A. J. Hutter, D. Morger, L. Opitz, L. Poveda, H. A. Keserue, C. Panse, B. Roschitzki & M. A. Seeger

gpcr.

2021  Nature

Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

Authors: C. Hong, N. J. Byrne, B. Zamlynny, S. Tummala, L. Xiao, J. M. Shipman, A. T. Partridge, C. Minnick, M. J. Breslin, M. T. Rudd, S. J. Stachel, V. L. Rada, J. C. Kern, K. A. Armacost, S. A. Hollingsworth, J. A. O’Brien, D. L. Hall, T. P. McDonald, C. Strickland, A. Brooun, S. M. Soisson, K. Hollenstein

2020  eLife

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

Authors: C. J. Tsai, J. Marino, R. Adaixo, F. Pamula, J. Muehle, S. Maeda, T. Flock, N. M. Taylor, I. Mohammed, H. Matile, R. J. P. Dawson, X. Deupi, H. Stahlberg, G. Schertler

2019  Science

Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor

Authors: P. Bräuer, J. L. Parker, A. Gerondopoulos, I. Zimmermann, M. A. Seeger, F. A. Barr, S. Newstead

2019  Cell

Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7

Authors: K. Jaeger, S. Bruenle, T. Weinert, W. Guba, J. Muehle, T. Miyazaki, M. Weber, A. Furrer, N. Haenggi, T. Tetaz, C. Y. Huang, D. Mattle, J. M. Vonach, A. Gast, A. Kuglstatter, M. G. Rudolph, P. Nogly, J. Benz, R. J. P. Dawson, J. Standfuss

2018  PNAS

Ligand channel in pharmacologically stabilized rhodopsin

Authors: D. Mattle, B. Kuhn, J. Aebi, M. Bedoucha, D. Kekilli, N. Grozinger, A. Alker, M. G. Rudolph, G. Schmid, G. F. X. Schertler, M. Hennig,J. Standfuss, R. J. P. Dawson

2018  Nature

Structure of the µ-opioid receptor–Gi protein complex

Authors: A. Koehl, H. Hu, S. Maeda, Y. Zhang, Q. Qu, J. M. Paggi, N. R. Latorraca, D. Hilger, R. Dawson, H. Matile, G. F. X. Schertler, S. Granier, W. I. Weis, R. O. Dror, A. Manglik, G. Skiniotis, B. K. Kobilka

other.

2022 EMBOpress

Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance

Authors: J. D. Walter, M. Scherer, C. A. J. Hutter, A. A. Garaeva, I. Zimmermann, M. Wyss, J. Rheinberger, Y. Ruedin, J. C. Earp, P. Egloff, M. Sorgenfrei, L. M. Hürlimann, I. Gonda, G. Meier, S. Remm, S. Thavarasah, G. van Geest R. Bruggmann, G. Zimmer, D. J. Slotboom, C. Paulino, P. Plattet, M. A. Seeger

2022 eLife

Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling

Authors: M. S. Straub, C. Alvadia, M. Sawicka, R. Dutzler

2021  Nature Communications

Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains

Authors: D. Deneka, S. Rutz, C. A. J. Hutter, M. A. Seeger, M. Sawicka, R. Dutzler

2020  bioRxiv

Synthetic nanobodies targeting the SARS-CoV-2 receptor-binding domain

Authors: J. D. Walter, C. A. J. Hutter, I. Zimmermann, J. Earp, P. Egloff, M. Sorgenfrei, L. M. Hürlimann, I. Gonda, G. Meier, S. Remm, S. Thavarasah, P. Plattet, M. A. Seeger