PUBLICATIONS

Linkster Therapeutics technology is peer-reviewed and published in leading international scientific journals including Nature, Cell and Science

technology.

2022 Science Advances

The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells

Authors: L. Galazzo, G. Meier, D. Januliene, K. Parey, D. D. Vecchis, B. Striednig, H. Hilbi, L. V. Schäfer, I. Kuprov, A. Moeller, E. Bordignon, M. A. Seeger

2020 Nature protocols

Generation of synthetic nanobodies against delicate proteins

Authors: I. Zimmermann, P. Egloff, C. A. J. Hutter, B. T. Kuhn, P. Bräuer, S. Newstead, R. J. P. Dawson, E. R. Geertsma, M. A. Seeger

2019 Nature methods

Engineered peptide barcodes for in-depth analyses of binding protein libraries

Authors: P. Egloff, I. Zimmermann, F. M. Arnold, C. A. J. Hutter, D. Morger, L. Opitz, L. Poveda, H. A. Keserue, C. Panse, B. Roschitzki & M. A. Seeger

2018 Nature Communications

Development of an antibody fragment that stabilizes GPCR/G-protein complexes

Authors: S. Maeda, A. Koehl, H. Matile, H. Hu, D. Hilger, G. F. X. Schertler, A. Manglik, G. Skiniotis, R. J. P. Dawson, B. K. Kobilka

2018 eLife

Synthetic single domain antibodies for the conformational trapping of membrane proteins

Authors: I. Zimmermann, P. Egloff, C. A. J. Hutter, F. M. Arnold, P. Stohler, N. Bocquet, M. N. Hug, S. Huber, M. Siegrist, L. Hetemann, J. Gera, S. Gmür, P. Spies, D. Gygax, E. R. Geertsma, R. J. P. Dawson, M. A. Seeger

Transporter.

2022 nature chemical biology

Deep mutational scan of a drug efflux pump reveals its structure–function landscape

Authors: G. Meier, S. Thavarasah, K. Ehrenbolger, C. A. J. Hutter, L.M. Hürlimann, J. Barandun & M. A. Seeger

2022 Nature Communications

Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation

Authors: M. Botte, D. Ni, S. Schenck, I. Zimmermann, M. Chami, N. Bocquet, P. Egloff, D. Bucher, M. Trabuco, R. K. Y. Cheng, J. D. Brunner, M. A. Seeger, H. Stahlberg & M. Hennig

2022 Science Advances

Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification

Authors: N. Bärland, A. Rueff, G. Cebrero, C. A. J. Hutter, M. A. Seeger, J. Veening, C. Perez

2021 Nature

Kinetic mechanism of Na+-coupled aspartate transport catalyzed by GltTk

Authors: G. Trinco, V. Arkhipova, A. A. Garaeva, C. A. J. Hutter, M. A. Seeger, A. Guskov, D. J. Slotboom

2021 Nature

Structural insights into the inhibition of glycine reuptake

Authors: A. Shahsavar, P. Stohler, G. Bourenkov, I. Zimmermann, M. Siegrist, W. Guba, E. Pinard, S. Sinning, M. A. Seeger, T. R. Schneider, R. J. P. Dawson, P. Nissen

2020 Proc Natl Acad Sci U S A, 117(5): p. 2441-2448.

Spin-labeled nanobodies as protein conformational reporters for electron paramagnetic resonance in cellular membranes

Authors: L. Galazzo, G. Meier, M.H. Timachi, C.A.J. Hutter, M.A. Seeger*, and E. Bordignon*

2020 Nature

The ABC exporter IrtAB imports and reduces mycobacterial siderophores

Authors: F. M. Arnold, M. S. Weber, I. Gonda, M. J Gallenito, S. Adenau, P. Egloff, I. Zimmermann, C. A. J. Hutter, L. M. Hürlimann, E. E. Peters, J. Piel, G. Meloni, O. Medalia, M. A. Seeger

2019 Nature Communications

The extracellular gate shapes the energy profile of an ABC exporter

Authors: C. A. J. Hutter, M. H. Timachi, L. M. Hürlimann, I. Zimmermann, P. Egloff, H. Göddeke, S. Kucher, S. Štefanić, M. Karttunen, L. V. Schäfer, E. Bordignon & M. A. Seeger

2019 Nature methods

Engineered peptide barcodes for in-depth analyses of binding protein libraries

Authors: P. Egloff, I. Zimmermann, F. M. Arnold, C. A. J. Hutter, D. Morger, L. Opitz, L. Poveda, H. A. Keserue, C. Panse, B. Roschitzki & M. A. Seeger

gpcr.

2021 Nature

Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

Authors: C. Hong, N. J. Byrne, B. Zamlynny, S. Tummala, L. Xiao, J. M. Shipman, A. T. Partridge, C. Minnick, M. J. Breslin, M. T. Rudd, S. J. Stachel, V. L. Rada, J. C. Kern, K. A. Armacost, S. A. Hollingsworth, J. A. O’Brien, D. L. Hall, T. P. McDonald, C. Strickland, A. Brooun, S. M. Soisson, K. Hollenstein

2020 eLife

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

Authors: C. J. Tsai, J. Marino, R. Adaixo, F. Pamula, J. Muehle, S. Maeda, T. Flock, N. M. Taylor, I. Mohammed, H. Matile, R. J. P. Dawson, X. Deupi, H. Stahlberg, G. Schertler

2019 Science

Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor

Authors: P. Bräuer, J. L. Parker, A. Gerondopoulos, I. Zimmermann, M. A. Seeger, F. A. Barr, S. Newstead

2019 Cell

Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7

Authors: K. Jaeger, S. Bruenle, T. Weinert, W. Guba, J. Muehle, T. Miyazaki, M. Weber, A. Furrer, N. Haenggi, T. Tetaz, C. Y. Huang, D. Mattle, J. M. Vonach, A. Gast, A. Kuglstatter, M. G. Rudolph, P. Nogly, J. Benz, R. J. P. Dawson, J. Standfuss

2018 PNAS

Ligand channel in pharmacologically stabilized rhodopsin

Authors: D. Mattle, B. Kuhn, J. Aebi, M. Bedoucha, D. Kekilli, N. Grozinger, A. Alker, M. G. Rudolph, G. Schmid, G. F. X. Schertler, M. Hennig,J. Standfuss, R. J. P. Dawson

2018 Nature

Structure of the µ-opioid receptor–Gi protein complex

Authors: A. Koehl, H. Hu, S. Maeda, Y. Zhang, Q. Qu, J. M. Paggi, N. R. Latorraca, D. Hilger, R. Dawson, H. Matile, G. F. X. Schertler, S. Granier, W. I. Weis, R. O. Dror, A. Manglik, G. Skiniotis, B. K. Kobilka

other.

2022 EMBOpress

Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance

Authors: J. D. Walter, M. Scherer, C. A. J. Hutter, A. A. Garaeva, I. Zimmermann, M. Wyss, J. Rheinberger, Y. Ruedin, J. C. Earp, P. Egloff, M. Sorgenfrei, L. M. Hürlimann, I. Gonda, G. Meier, S. Remm, S. Thavarasah, G. van Geest R. Bruggmann, G. Zimmer, D. J. Slotboom, C. Paulino, P. Plattet, M. A. Seeger

2022 eLife

Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling

Authors: M. S. Straub, C. Alvadia, M. Sawicka, R. Dutzler

2021 Nature Communications

Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains

Authors: D. Deneka, S. Rutz, C. A. J. Hutter, M. A. Seeger, M. Sawicka, R. Dutzler

2020 bioRxiv

Synthetic nanobodies targeting the SARS-CoV-2 receptor-binding domain

Authors: J. D. Walter, C. A. J. Hutter, I. Zimmermann, J. Earp, P. Egloff, M. Sorgenfrei, L. M. Hürlimann, I. Gonda, G. Meier, S. Remm, S. Thavarasah, P. Plattet, M. A. Seeger

PUBLICATIONS

technology.

2022 Science Advances

The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells

2020 Nature protocols

Generation of synthetic nanobodies against delicate proteins

2019 Nature methods

Engineered peptide barcodes for in-depth analyses of binding protein libraries

2018 Nature Communications

Development of an antibody fragment that stabilizes GPCR/G-protein complexes

2018 eLife

Synthetic single domain antibodies for the conformational trapping of membrane proteins

Transporter.

2022 nature chemical biology

Deep mutational scan of a drug efflux pump reveals its structure–function landscape

2022 Nature Communications

Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation

2022 Science Advances

Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification

2021 Nature

Kinetic mechanism of Na+-coupled aspartate transport catalyzed by GltTk

2021 Nature

Structural insights into the inhibition of glycine reuptake

2020 Proc Natl Acad Sci U S A, 117(5): p. 2441-2448.

Spin-labeled nanobodies as protein conformational reporters for electron paramagnetic resonance in cellular membranes

2020 Nature

The ABC exporter IrtAB imports and reduces mycobacterial siderophores

2019 Nature Communications

The extracellular gate shapes the energy profile of an ABC exporter

2019 Nature methods

Engineered peptide barcodes for in-depth analyses of binding protein libraries

gpcr.

2021 Nature

Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

2020 eLife

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

2019 Science

Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor

2019 Cell

Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7

2018 PNAS

Ligand channel in pharmacologically stabilized rhodopsin

2018 Nature

Structure of the µ-opioid receptor–Gi protein complex

other.

2022 EMBOpress

Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance

2022 eLife

Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling

2021 Nature Communications

Allosteric modulation of LRRC8 channels by targeting their cytoplasmic domains

2020 bioRxiv

Synthetic nanobodies targeting the SARS-CoV-2 receptor-binding domain

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